Monique David-Dufilho
monique.dufilho@brs.aphp.fr
Address
UMR7131 CNRS-Université Pierre et Marie Curie Paris6
Signalisation cellulaire, hémodynamique circulatoire et athérosclérose précoce
Hôpital Broussais-HEGP
102 rue Didot
75014 Paris
Interests
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Endothelial nitric oxide metabolism
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Cardiovascular system and diseases
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Signal transduction
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Oxidative stress
Qualifications
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1990: Ph. D: “Regulation of the intracellular Ca 2+ concentration in red blood cells and cardiac myocytes: alterations in primary hypertension”, Pierre and Marie Curie University , Paris 6, France
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1984: 3 rd cycle thesis : “Transport of sodium and calcium ions through the cardiac sarcolemma of spontaneously hypertensive rats”, Pierre and Marie Curie University , Paris 6, France
Career History
Monique david-Dufilho is researcher at CNRS from 1988. During 10 years, she worked in the field of the intracellular messenger calcium at the Necker's Hospital, Paris . Her focus of interest was the cellular calcium transport systems of blood and cardiac cells and their deregulation in human and experimental hypertension and cardiac hypertrophy with special attention to new potential therapeutics. From 1994, her work focused on calcium and nitric oxide metabolism at the vascular endothelium. She created her own group in 1995.
Her scientific theme now focuses on the role of oxidative stress and mitochondria in the uncoupling of endothelial NO synthase activity. Her other centre of interest is the involvement of the messenger NO in communication between blood cells and endothelium through the soluble and endothelial thrombin receptor thrombomodulin. She now works at Broussais-HEGP hospital, Paris.
Publication